#1 Health & Fitness ShowApple Podcasts
Lifespan Show
Discover the Science of Longevity
4.9 (6K)766K SUBSCRIBERSNEW EPISODES BIWEEKLY
Join Dr. David Sinclair, A.O., Ph.D., host of the #1 Health & Fitness podcast Lifespan, as he translates the latest longevity research into practical, evidence-based insights. Explore topics including biological aging, nutrition, exercise, medications and supplements, and more.
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Episodes
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Season S2 / Episode 4 72 minJul 23, 2026Inside the World's First Age Reversal Trial
In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. explores the science of eye aging, vision loss, and emerging strategies to preserve vision throughout life. Dr. Sinclair shares an exclusive update on ER-100, including his team's successful restoration of vision in non-human primates and the launch of the world's first FDA-cleared age reversal human clinical trial. This Phase 1 clinical trial will evaluate the safety of epigenetic cellular restoration as a therapy. Additionally, drawing on decades of research, Dr. Sinclair explains why the eyes may offer one of the earliest windows into biological aging, how everyday factors such as sleep position, alcohol consumption, and intraocular pressure influence long-term eye health, and what the latest evidence reveals about nutrition, supplements, and the connection between the eyes and the brain. Whether you're interested in longevity, brain health, or protecting your eyesight, this episode provides an evidence-based look at the biology of vision and the future of regenerative medicine.
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Season S2 / Episode 3 68 minJul 10, 2026What to Eat & When to Eat for Longevity: New Science
In this second installment of Lifespan's two-part series on calorie restriction and fasting, Dr. David Sinclair, A.O., Ph.D. evaluates how to fast effectively for health and longevity. Drawing on decades of research and the latest scientific evidence, Dr. Sinclair explains how to approach fasting effectively, what happens inside your body at the 12-, 24-, and 48+-hour marks, how to overcome common plateaus, and the key considerations for women, men, and people at different stages of life. Whether you're new to fasting or looking to refine your approach, this episode provides a practical, evidence-based guide to using fasting to support metabolism, cellular repair, and healthy longevity.
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Season S2 / Episode 1 66 minJun 11, 2026The Longevity Revolution Is Here
In this first all-new episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. returns and investigates one of the most consequential questions in science: How can aging be slowed or reversed? Drawing on more than 25 years of research at the forefront of aging biology, Dr. Sinclair explains why humanity has entered a revolutionary period. Advances in science and technology have converged and transformed aging into a promising target for intervention. This episode is a sweeping introduction to the science, breakthroughs, and emerging technologies that are fundamentally reshaping how we think about aging, disease, and the future of human health.
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Season S2 / Episode 2 75 minJun 25, 2026Fasting as a Path to Longevity: The Facts
In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. examines the science of calorie restriction and fasting, two of the most studied interventions for healthy aging. Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk. Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.
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Season S1 / Episode 4 71 minJan 27, 2022NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4
In this week's episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
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Season S1 / Episode 6 70 minFeb 10, 2022The Science of Looking Younger, Longer | Lifespan with Dr. David Sinclair #6
In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.
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Season S1 / Episode 8 70 minFeb 24, 2022Biotracking, Age Reversal & Other Advanced Health Technologies | Lifespan with Dr. David Sinclair #8
In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered.
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Season S1 / Episode 5 59 minFeb 3, 2022Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5
In this week's episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.
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Season S1 / Episode 7 62 minFeb 17, 2022The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7
In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.
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Season S1 / Episode 3 72 minJan 20, 2022Exercise, Heat, Cold & Other Stressors for Longevity | Lifespan with Dr. David Sinclair #3
In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.
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Season S1 / Episode 2 68 minJan 13, 2022What to Eat & When to Eat for Longevity | Lifespan with Dr. David Sinclair #2
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity.
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Season S1 / Episode 1 72 minJan 5, 2022The Science Behind Why We Age
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.
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Audience Reviews
+98%180,000 Votes
4.9/55,900 Reviews
4.9/54,400 ReviewsSuch hopeful research! My daughter’s optic nerves were crushed by a brain tumor, and listening to you talk about your aging research beginning with fixing loss of sight is just amazing. Brought me to tears thinking of the possibilities for her, hopefully sooner than later. I loved every episode of this series and can’t wait for the next season.
JayneSays
Smart, evidence-based insights. No fluff - just simple, practical takeaways you can actually use. Can't wait for Season 2.
jcchadwick
If you are interested in aging, this is a must listen. Even if you’ve read Dr. Sinclair’s book “Lifespan,” a lot of advancements have been made in the brief time since it was written. This podcast offers easy to understand explanations of the science of aging and practical advice...
Keith1950
Such hopeful research! My daughter’s optic nerves were crushed by a brain tumor, and listening to you talk about your aging research beginning with fixing loss of sight is just amazing. Brought me to tears thinking of the possibilities for her, hopefully sooner than later. I loved every episode of this series and can’t wait for the next season.
JayneSays
Smart, evidence-based insights. No fluff - just simple, practical takeaways you can actually use. Can't wait for Season 2.
jcchadwick
If you are interested in aging, this is a must listen. Even if you’ve read Dr. Sinclair’s book “Lifespan,” a lot of advancements have been made in the brief time since it was written. This podcast offers easy to understand explanations of the science of aging and practical advice...
Keith1950
Such hopeful research! My daughter’s optic nerves were crushed by a brain tumor, and listening to you talk about your aging research beginning with fixing loss of sight is just amazing. Brought me to tears thinking of the possibilities for her, hopefully sooner than later. I loved every episode of this series and can’t wait for the next season.
JayneSays
Smart, evidence-based insights. No fluff - just simple, practical takeaways you can actually use. Can't wait for Season 2.
jcchadwick
If you are interested in aging, this is a must listen. Even if you’ve read Dr. Sinclair’s book “Lifespan,” a lot of advancements have been made in the brief time since it was written. This podcast offers easy to understand explanations of the science of aging and practical advice...
Keith1950
Best podcast I've heard and I'm a podcast addict. High level information, newest research and things you just won't hear in other places but broken up in a way that I can understand.
Sarah Messali
I have completely restored my deep sleep cycle by following the suggested intermittent fasting and getting all my eating finished before 2pm. Can’t thank these guys enough, wish I could use more of their wisdom, awaiting season 2 with excitement.
amacfly
If I could give your podcast 10 Stars, I would! I’ve learned a ridiculous amount of information about my own body and the science of aging. My parents died early (age 65 and 67) from undiagnosed cancer and a sudden aortic aneurysm.
OULYB
Best podcast I've heard and I'm a podcast addict. High level information, newest research and things you just won't hear in other places but broken up in a way that I can understand.
Sarah Messali
I have completely restored my deep sleep cycle by following the suggested intermittent fasting and getting all my eating finished before 2pm. Can’t thank these guys enough, wish I could use more of their wisdom, awaiting season 2 with excitement.
amacfly
If I could give your podcast 10 Stars, I would! I’ve learned a ridiculous amount of information about my own body and the science of aging. My parents died early (age 65 and 67) from undiagnosed cancer and a sudden aortic aneurysm.
OULYB
Best podcast I've heard and I'm a podcast addict. High level information, newest research and things you just won't hear in other places but broken up in a way that I can understand.
Sarah Messali
I have completely restored my deep sleep cycle by following the suggested intermittent fasting and getting all my eating finished before 2pm. Can’t thank these guys enough, wish I could use more of their wisdom, awaiting season 2 with excitement.
amacfly
If I could give your podcast 10 Stars, I would! I’ve learned a ridiculous amount of information about my own body and the science of aging. My parents died early (age 65 and 67) from undiagnosed cancer and a sudden aortic aneurysm.
OULYB
Such hopeful research! My daughter’s optic nerves were crushed by a brain tumor, and listening to you talk about your aging research beginning with fixing loss of sight is just amazing. Brought me to tears thinking of the possibilities for her, hopefully sooner than later. I loved every episode of this series and can’t wait for the next season.
JayneSays
Best podcast I've heard and I'm a podcast addict. High level information, newest research and things you just won't hear in other places but broken up in a way that I can understand.
Sarah Messali
Smart, evidence-based insights. No fluff - just simple, practical takeaways you can actually use. Can't wait for Season 2.
jcchadwick
I have completely restored my deep sleep cycle by following the suggested intermittent fasting and getting all my eating finished before 2pm. Can’t thank these guys enough, wish I could use more of their wisdom, awaiting season 2 with excitement.
amacfly
If you are interested in aging, this is a must listen. Even if you’ve read Dr. Sinclair’s book “Lifespan,” a lot of advancements have been made in the brief time since it was written. This podcast offers easy to understand explanations of the science of aging and practical advice...
Keith1950
If I could give your podcast 10 Stars, I would! I’ve learned a ridiculous amount of information about my own body and the science of aging. My parents died early (age 65 and 67) from undiagnosed cancer and a sudden aortic aneurysm.
OULYB
+98%180,000 Votes
4.9/55,900 Reviews
4.9/54,400 Reviews