The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1

The Lifespan Podcast

The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1

• 30 mins

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.

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The Science of Living Longer

Inspired by David Sinclair’s Lifespan: Why We
Age—and Why We Don’t Have To

Episode Overview

In this episode, we explore the groundbreaking ideas from Lifespan, where biologist David Sinclair argues that aging is a disease — and one that can be treated. We’ll discuss the science of longevity, how lifestyle choices impact our biological age, and what it means to live healthier, longer lives.

“Aging is a disease, and that disease is treatable.” — David Sinclair

Introduction

Host greets listeners and introduces the episode’s theme: “Can we slow, or even reverse, the process of aging?”
Brief context on David Sinclair and his work at Harvard.
Personal reflection or hook: how the idea of “reversing age” challenges everything we think we know about life.

00:00

David Sinclair

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00:15

John Doe

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00:24

David Sinclair

01:15

John Doe

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The Science of Living Longer Inspired by David Sinclair’s Lifespan: Why We Age—and Why We Don’t Have To Episode Overview In this episode, we explore the groundbreaking ideas from Lifespan, where biologist David Sinclair argues that aging is a disease — and one that can be treated. We’ll discuss the science of longevity, how lifestyle choices impact our biological age, and what it means to live healthier, longer lives. “Aging is a disease, and that disease is treatable.” — David Sinclair Introduction Host greets listeners and introduces the episode’s theme: “Can we slow, or even reverse, the process of aging?” Brief context on David Sinclair and his work at Harvard. Personal reflection or hook: how the idea of “reversing age” challenges everything we think we know about life.

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