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INTERVIEWS

From Bedside to Cloud: Dr. David Rhew on Using AI to Help Us Age Well

Dr. David Rhew is a physician, researcher, and technologist who has spent his career trying to make healthcare both smarter and more humane. He is currently the Global Chief Medical...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Sep 6, 20268 minute read

NEW RESEARCH EXERCISE

Does Rapamycin Block the Benefits of Exercise?

Many, many miles west of South America lies a small, triangle-shaped island housing hundreds of ancient, giant stone statues. The native name for this island is Rapa Nui and, in...

Dr. Adiv Johnson, Ph.D.

Sep 6, 20264 minute read

NEW RESEARCH OPINION

How Long Can We Actually Expect to Live in The Coming Years?

Most longevity or wellness enthusiasts have heard of things like free radicals or oxidative stress. Perhaps you've seen supplements or foods labeled with "antioxidants" or actively seek out antioxidant-containing products...

Dr. Adiv Johnson, Ph.D.

Sep 6, 20265 minutes read

NEW RESEARCH OPINION

Blood NAD+ Levels Tell Us Less Than Many People Think

One of the easiest mistakes in science is to confuse a single measurement with the whole reality. We do it all the time. An investor watches a stock price and...

Dr. David A. Sinclair, A.O., Ph.D.

Sep 6, 202611 minute read

EDITORIALS FEATURES OPINION BUSINESS ETHICS

Why the Greatest Opportunity of Our Time Is Portrayed as a Vanity Project

Longevity science now occupies that uncomfortable territory between ridicule and inevitability. History repeatedly shows that this is how transformative ideas begin. Days before the Wright brothers achieved powered flight in...

Dr. David A. Sinclair, A.O., Ph.D.

Sep 6, 202610 minute read

FEATURES NEW RESEARCH

The Mosaic Body

We usually talk about age as a single number. You blow out one more candle each year and you select a single age bracket on surveys and medical forms. Pediatric...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Sep 6, 202619 minute read

FEATURES MEN'S HEALTH EXERCISE

Four Negotiations Every Man Has With Time

In last month’s issue, I wrote about women’s aging through the lens of ovarian shutdown. Menopause is often framed as a cliff: one organ changes its behavior around 50, the...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Sep 6, 202616 minute read

FEATURES NEW RESEARCH

The Heritability of Lifespan

There’s a familiar character in modern medicine: the perfect patient. The person who does everything “right.” They eat sensibly, exercise regularly, avoid obvious vices, keep up with screenings, floss every...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Sep 6, 202610 minute read

FEATURES OPINION

Daily Aspirin: The Story Isn't Over

One of the biggest challenges in medicine is that most people, including many physicians, don't read scientific papers. Instead, they learn about scientific breakthroughs through colleagues, journalists, TV commentators, podcasters,...

Dr. David A. Sinclair, A.O., Ph.D.

Sep 6, 202611 minute read

FEATURES NEW RESEARCH

Semaglutide and the Longevity Question

There has been plenty of chatter about whether GLP-1 drugs might be longevity drugs in disguise. A new study in Nature adds the most direct preclinical evidence yet: semaglutide extended...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Sep 6, 20268 minute read

OPINION ETHICS

Healthspan as a Family Value

On September 6, 2025, the Wall Street Journal published an article with the sensational headline, “The Billionaires Fueling the Quest for Longer Life.”1 The article was accompanied by a picture...

Carolyn B. Ringel, J.D., M.B.E.

Aug 7, 20263 minute read

FEATURES NEW RESEARCH

When Cells Forget: Inside the Information Theory of Aging

A patient sits in the exam room, waiting to be seen by his doctor. His mind drifts, as it often does, to his family. He pictures his granddaughter’s face –...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Aug 7, 202619 minute read

FEATURES NEW RESEARCH

The “Love Hormone” That Adds 73% More Life (to Mice)

Several years ago, I got stuck in a monstrous traffic jam while heading to the Phoenix airport on Interstate 10. It was the kind of situation where cars were completely...

Dr. Adiv Johnson, Ph.D.

Aug 7, 202611 minute read

FEATURES NEW RESEARCH

The Slime of Youth: What Naked Mole-Rats Teach Us About Aging

While most aging researchers study mice or human cells, Dr. Vera Gorbunova and her husband Dr. Andrei Seluanov built their careers studying – and mixing – the genes of whales,...

Dr. Adiv Johnson, Ph.D.

Aug 7, 20268 minute read

FEATURES EDITORIALS OPINION BUSINESS

Welcome to Lifespan: A Founding Editorial

Welcome to Lifespan. This is a magazine created for you, the reader. Thank you for subscribing. Together, we are going to do amazing things. If you love life and want...

Dr. David A. Sinclair, A.O., Ph.D.

Aug 7, 202611 minute read

INTERVIEWS NEW RESEARCH

Beyond Your Birthday: Steve Horvath on the Science of Epigenetic Aging

Dr. Steve Horvath is a biostatistician and researcher best known for discovering “epigenetic clocks,” mathematical models that estimate a person’s biological age by reading chemical tags known as DNA methylation...

Dr. Kelly Rich, M.S., C.G.C., Ph.D.

Aug 7, 20265 minute read

NEW RESEARCH EXERCISE

Dogs May Improve Cancer Survival

Over the past 15,000 years, humans and dogs have shared nearly five thousand canine generations of coevolution. That’s enough to change an animal from a predator you fear to a...

Dr. David A. Sinclair, A.O., Ph.D.

Aug 7, 20263 minute read

NEW RESEARCH NUTRITION

Can a Simple Multivitamin-Mineral Supplement Slow Down Aging?

You’ve probably heard the debate about whether taking a daily multivitamin is a good idea. I’ve had this conversation countless times, and I’ll admit I’ve changed my mind more than...

Dr. Adiv Johnson, Ph.D.

Aug 7, 20263 minute read

NEW RESEARCH

The Master Clock of Clocks

There are two clocks in the body. One resets every morning with the rising sun. The other does not reset at all. It accumulates, recording the passage of years. For...

Dr. David A. Sinclair, A.O., Ph.D.,Dr. Adiv Johnson, Ph.D.

Aug 7, 20266 minute read

NEW RESEARCH OPINION

Can Overusing AI Impair Your Cognition?

The headlines for artificial intelligence (AI) have been outrageously sensational since the advent of OpenAI’s ChatGPT in November of 2022. Some headlines represent classical “doomer” perspectives and argue that societies...

Dr. Adiv Johnson, Ph.D.

Aug 7, 20268 minute read

NEW RESEARCH

Senolytic Trial in Skin, With Broader Implications

A California-based biotechnology company backed by Khosla Ventures has reported preliminary Phase 1 results for its experimental drug RLS-1496, a topical treatment designed to eliminate senescent cells in patients with...

Dr. David A. Sinclair, A.O., Ph.D.

Aug 7, 20264 minute read

NEW RESEARCH MEN'S HEALTH

The Thymus is Back

For decades, the thymus, a small organ tucked behind the breastbone, has been all but forgotten. Long thought to matter only in childhood and fade into irrelevance in adulthood, that...