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The Lifespan Magazine

September 2026

Using AI and Aging Clocks to Rethink Clinical Trials

Using AI and Aging Clocks to Rethink Clinical Trials
Dr. Alex Zhavoronkov and Dr. Feng Ren oversee the Suzhou Robotics Lab, site of rentosertib’s design and manufacture. Source: Insilico Media Kit

What do idiopathic pulmonary fibrosis, AI and aging have in common? One answer has emerged from the results of a recent study capturing attention across science and medicine. This study has shown that a drug intended to treat idiopathic pulmonary fibrosis (IPF) also shifts several blood-based measures of biological aging1. And, the drug was discovered with AI.2

Rentosertib, the drug in question, offers an unusual test case: it’s an AI-discovered drug which was developed for an age-associated disease. In a small sub-study of a larger clinical trial, patients who took rentosertib had a consistent decline in six blood-based aging clocks.…