For over a century, drug development has faced a persistent problem: spectacular results in mice, slow progress and disappointing results in humans.
That is why one of the most exciting papers to emerge recently is not another mouse study or clinical trial.
Published in Nature Biomedical Engineering,1 Professor Andreas Stahl, the Ruth Okey Chair in Metabolic Biology and Nutrition and his postdoc Dr. Lin Qi built a human aging-on-a-chip model from human white adipose tissue and liver, then exposed it to serum from younger and older donors. In just four days, the system induced multiple hallmarks of aging that normally…
